| Monitor Cell-Cell Interactions Between Vascular and Brain Cells | Real-time drug permeability across the BBB. |
| Neurotoxicity on the cells of the BBB. |
| Evaluate drugs that have a protective effect on the BBB |
| Investigate the effects of tumor cells on the BBB |
| Evaluate inflammatory effects on the BBB |
| Biomarker Analysis |
| Visualize and quantify the migration of immune cells |
| Genomic, proteomic, and metabolic analysis of normal and dysfunctional BBB. |
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| Neurodegenerative Diseases: Alzheimer’s and Parkinson’s Disease | Tau levels/ clearance assays |
| Toxic Aβ1-42 peptide exposure |
| LDH release measurement |
| NeuN cell viability assay |
| Alpha-synuclein aggregation quantification |
| Neuronal mitophagy assays (Tom20 Loss Quantification) |
| Cytoprotective assays |
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| Neuro-Inflammation | Lipopolysaccharide (LPS)-induced inflammation |
| Nitric oxide production |
| Microglia activation |
| Macrophage activation |
| Phagocytosis Assays |
| Human microglia assays: cytokine release & calcium imaging |
| Neuronal and microglial inflammation assays |
| Microglial activation & phagocytosis studies |
| Neuro-Glia co-cultures studies |
| Cytokine release assays |
| LPS-induced inflammation |
| Neurite outgrowth assays |
| Miscellaneous based on customers requirement subject to Feasibility |
